33 research outputs found

    Angiogenesis inhibitors in the treatment of prostate cancer

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    Prostate cancer remains a significant public health problem, with limited therapeutic options in the setting of castrate-resistant metastatic disease. Angiogenesis inhibition is a relatively novel antineoplastic approach, which targets the reliance of tumor growth on the formation of new blood vessels. This strategy has been used successfully in other solid tumor types, with the FDA approval of anti-angiogenic agents in breast, lung, colon, brain, and kidney cancer. The application of anti-angiogenic therapy to prostate cancer is reviewed in this article, with attention to efficacy and toxicity results from several classes of anti-angiogenic agents. Ultimately, the fate of anti-angiogenic agents in prostate cancer rests on the eagerly anticipated results of several key phase III studies

    Network coded MIMO aided cooperative communications in the ambulance-and-emergency area

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    In this contribution, a novel network coding (NC) aided multi-input multi-output (MIMO) scheme is proposed for providing reliable transmission from an ambulance assisting in an emergency situation by cooperating with relaying devices at an emergency scene. Our system is constituted by an Irregular Convolutional Coded Unity Rate Coded Space Time Trellis Coded M-ary Phase Shift Keying (IrCC-URC-STTC-MPSK) scheme invoked for exploiting the benefits of MIMO systems. The system is designed with the aid of Extrinsic Information Transfer (EXIT) charts for approaching the corresponding channel capacity in fast fading environments. The proposed scheme exhibits substantial benefits over conventional MIMO systems in hostile wireless channels

    COVID-19 in the Lombardy region: socio-spatial peripheries and forgotten densities of long-term care

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    This chapter addresses the crisis of care in Lombardy region, which has been substantially impacted by the COVID-19 pandemic. Although it is one of the wealthiest regions in Europe, during the pandemic Lombardy revealed emerging social and spatial peripheries of the contemporary society, identified in suburban contexts that results from non-linear processes of extended urbanization. Addressing the impacts of the virus on health infrastructures, and relying on the recent literature, the chapter examines a particular type of ‘forgotten density’ – institutional environments like long-term care homes – that should be central to public health, but have been shown to be ill-prepared for COVID-19

    ACCENTS: a Vision for D2D Communications within 5G Networks

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    International audienceThe paper presents the studies that have been led toward the integration of device-to-device (D2D) communications within LTE networks in the frame of the project ACCENTS (Advanced Waveforms, MAC Design and Dynamic Radio Resource Allocation for Device-to-Device in SG Wireless Networks) supported by the French National Research Agency. The solutions presented in this paper cover several aspects of D2D communications; they are the result of a close cooperation between four partners: Thales Communications and Security, CNAM, TeamCast and CentraleSupelec. Physical Layer aspects have been investigated, especially concerning waveforms envisioned for D2D communications within SG networks. Also, a new MAC protocol has been designed to address the issues raised by the integration of D2D transmissions within LTE cells. The solution coming out of the study guarantees a minimum QoS for both types of users (D2D users and regular users) and aims at reusing spectrum while offloading the burden on the base station
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